{"id":513,"date":"2020-10-30T15:28:02","date_gmt":"2020-10-30T08:28:02","guid":{"rendered":"http:\/\/ginafertilitystudio.com\/?page_id=513"},"modified":"2024-08-08T16:14:13","modified_gmt":"2024-08-08T09:14:13","slug":"service-pgt","status":"publish","type":"page","link":"http:\/\/ginafertilitystudio.com\/en\/service-pgt\/","title":{"rendered":"Service PGT"},"content":{"rendered":"

[et_pb_section fb_built=”1″ module_class=”section-slider” _builder_version=”4.5.3″ _module_preset=”default” background_image=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2024\/07\/new-banner-services.jpg” custom_padding=”280px||||false|false” custom_css_main_element=”height: 800px;” global_module=”787″ saved_tabs=”all”][et_pb_row _builder_version=”4.16″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”text-align: center;”][et_pb_text admin_label=”\u0e02\u0e49\u0e2d\u0e04\u0e27\u0e32\u0e21” _builder_version=”4.5.3″ _module_preset=”default” header_2_font=”anuphan-regular||||||||” header_3_font=”anuphan-regular||||||||” header_3_font_size=”19px” text_orientation=”center” custom_padding=”20px||||false|false”]<\/p>\n

\u201c A child is a miracle<\/h2>\n

and gift we can create.\u201d<\/h2>\n

Gina fertility studio<\/h3>\n

[\/et_pb_text][et_pb_button button_url=”\/contact-us\/##contact-info” button_text=”\u0e2a\u0e19\u0e43\u0e08\u0e23\u0e31\u0e1a\u0e04\u0e33\u0e1b\u0e23\u0e36\u0e01\u0e29\u0e32” button_alignment=”center” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_bg_color=”rgba(0,0,0,0)” button_border_color=”#ffffff” button_border_radius=”10px” button_icon_color=”#ffffff”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.3″ _module_preset=”default” hover_enabled=”0″ background_enable_image=”off” background_color=”#fabfb7″][et_pb_row _builder_version=”4.5.3″ _module_preset=”default” custom_margin=”|auto||auto|false|false” custom_padding=”0px|||||” global_module=”448″ saved_tabs=”all”][et_pb_column type=”4_4″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” header_font=”anuphan-regular|600|||||||” header_text_color=”#801922″ text_orientation=”center”]<\/p>\n

Our Service<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ module_class=”bg-dark” _builder_version=”4.6.6″ _module_preset=”default” global_module=”456″][et_pb_column type=”1_3″ module_class=”col-service-nav-1″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_image src=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2020\/10\/service-1-white.png” title_text=”service-1-white” align=”center” _builder_version=”4.6.6″ _module_preset=”default” custom_margin=”||0px||false|false”][\/et_pb_image][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” text_text_color=”#000000″ header_text_color=”#0c71c3″ header_4_text_color=”#801922″ header_5_text_color=”#801922″ text_orientation=”center” custom_margin=”||10px||false|false”]<\/p>\n

Intrauterine insemination<\/h4>\n

( Intrauterine insemination, IUI )<\/h5>\n

[\/et_pb_text][et_pb_button button_url=”\/service-iui” button_text=”More Detail” button_alignment=”center” _builder_version=”4.5.3″ _module_preset=”default” custom_button=”on” button_border_color=”#ffffff” button_border_radius=”10px” hover_enabled=”0″ button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#f6968e” button_text_color=”#ffffff” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#ffffff” button_bg_enable_color__hover=”on”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ module_class=”col-service-nav-2″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_image src=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2020\/10\/service-2-white.png” title_text=”service-2-white” align=”center” _builder_version=”4.6.6″ _module_preset=”default” custom_margin=”||0px||false|false”][\/et_pb_image][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” header_4_text_color=”#801922″ header_5_text_color=”#801922″ text_orientation=”center” custom_margin=”||10px||false|false”]<\/p>\n

Testicular Sperm Extraction <\/h4>\n

( Testicular Sperm Extraction, TESE )<\/h5>\n

[\/et_pb_text][et_pb_button button_url=”\/service-tese” button_text=”More Detail” button_alignment=”center” _builder_version=”4.5.3″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_border_color=”#ffffff” button_border_radius=”10px” button_text_color__hover_enabled=”on|hover” hover_enabled=”0″ button_text_color__hover=”#f6968e” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#ffffff” button_bg_enable_color__hover=”on”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ module_class=”col-service-nav-3″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_image src=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2020\/10\/service-3-white.png” title_text=”service-3-white” align=”center” _builder_version=”4.6.6″ _module_preset=”default” custom_margin=”||0px||false|false”][\/et_pb_image][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” header_4_text_color=”#801922″ header_5_text_color=”#801922″ text_orientation=”center” custom_margin=”||10px||false|false”]<\/p>\n

IVF<\/h4>\n

( In Vitro fertilization )<\/h5>\n

[\/et_pb_text][et_pb_button button_url=”\/service-ivf” button_text=”More Detail” button_alignment=”center” _builder_version=”4.5.3″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_border_color=”#ffffff” button_border_radius=”10px” hover_enabled=”0″ button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#f6968e” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#ffffff” button_bg_enable_color__hover=”on”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ module_class=”bg-dark” _builder_version=”4.6.6″ _module_preset=”default” global_module=”457″][et_pb_column type=”1_3″ module_class=”col-service-nav-4″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_image src=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2020\/10\/service-4-white.png” title_text=”service-4-white” align=”center” _builder_version=”4.6.6″ _module_preset=”default” custom_margin=”||0px||false|false”][\/et_pb_image][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” header_4_text_color=”#801922″ header_5_text_color=”#801922″ text_orientation=”center” custom_margin=”||10px||false|false”]<\/p>\n

ICSI<\/h4>\n

( Intra Cytoplasmic Sperm Injection )<\/h5>\n

[\/et_pb_text][et_pb_button button_url=”\/service-icsi” button_text=”More Detail” button_alignment=”center” _builder_version=”4.5.3″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_border_color=”#ffffff” button_border_radius=”10px” hover_enabled=”0″ button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#f6968e” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#ffffff” button_bg_enable_color__hover=”on”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ module_class=”col-service-nav-5″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_image src=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2020\/10\/service-5-white.png” title_text=”service-5-white” align=”center” _builder_version=”4.6.6″ _module_preset=”default” custom_margin=”||0px||false|false”][\/et_pb_image][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” header_4_text_color=”#801922″ header_5_text_color=”#801922″ text_orientation=”center” custom_margin=”||10px||false|false”]<\/p>\n

Oocyte\/Sperm\/
\nEmbryo Cryopreservation<\/h4>\n

( Oocyte\/Sperm\/
Embryo Cryopreservation )<\/h5>\n

[\/et_pb_text][et_pb_button button_url=”\/service-osec” button_text=”More Detail” button_alignment=”center” _builder_version=”4.5.3″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_border_color=”#ffffff” button_border_radius=”10px” hover_enabled=”0″ button_text_color__hover_enabled=”on|hover” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#ffffff” button_bg_enable_color__hover=”on” button_text_color__hover=”#f6968e”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ module_class=”col-service-nav-6″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_image src=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2020\/10\/service-6-white.png” title_text=”service-6-white” align=”center” _builder_version=”4.6.6″ _module_preset=”default” custom_margin=”||0px||false|false”][\/et_pb_image][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” header_text_color=”#801922″ header_4_text_color=”#801922″ header_5_text_color=”#801922″ text_orientation=”center” custom_margin=”||10px||false|false”]<\/p>\n

Pre-implantation
Genetic Testing<\/h4>\n

( Pre-implantation Genetic Testing,
PGT )<\/h5>\n

[\/et_pb_text][et_pb_button button_url=”\/service-pgt” button_text=”More Detail” button_alignment=”center” _builder_version=”4.5.3″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_border_color=”#ffffff” button_border_radius=”10px” hover_enabled=”0″ button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#f6968e” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#ffffff” button_bg_enable_color__hover=”on”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”section-service-content” _builder_version=”4.5.3″ _module_preset=”default” background_enable_image=”off” background_size=”initial”][et_pb_row _builder_version=”4.6.6″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.6.6″ _module_preset=”default”][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” header_2_font=”anuphan-regular||||||||” header_2_text_color=”#801922″ header_3_font=”anuphan-regular||||||||” header_3_text_color=”#801922″]<\/p>\n

Pre-implantation
Genetic Testing<\/h2>\n

( Pre-implantation Genetic Testing, PGT )<\/h3>\n

[\/et_pb_text][et_pb_image src=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2020\/10\/service-6-color.png” title_text=”service-6-color” _builder_version=”4.6.6″ _module_preset=”default”][\/et_pb_image][et_pb_text _builder_version=”4.5.3″ _module_preset=”default” text_font=”anuphan-regular||||||||” text_text_color=”#801922″ header_3_font=”anuphan-regular||||||||” header_3_text_color=”#801922″]<\/p>\n

Pre-implantation Genetic Testing (PGT) is to screen the chromosome or genetic materials of the embryo before \ntransferring it to the woman\u2019s uterus to determine the genetic disorder. PGT is classified into Preimplantation Genetic \nTesting for Aneuploidy (PGT-A) and Preimplantation Genetic Testing for Mutation (PGT-M).<\/p>\n

PGT is possible for the following cases:<\/h3>\n
    \n
  1. A man or woman or both of them have a background of genetic disease that might be transferred to the linear, \nwhich has a risk of non-survival or abnormality.<\/li>\n
  2. A man or woman who has no genetic disorder might take PGT in the following cases:\n
      \n
    1. Have a history of pregnancy that the baby has a severe genetic disorder that might be prevented by \nPGT.<\/li>\n
    2. Have a child with the disease that can be treated with stem cell transplantation from another child \nwith HLA matching.
      Embryo\u2019s HLA testing before transferring is useful. With embryo pregnancy, stem cells from \ncordocentesis can treat the ill child with HLA matching.<\/li>\n
    3. Have a history of 2-3 miscarriages or more before 12 weeks, or the examination result demonstrates \nthat the cause of previous carriage is the genetic disorder in a baby.<\/li>\n
    4. A woman aged 35 years old or over with a medical indication that the embryo has a risk of a genetic \ndisorder.<\/li>\n
    5. No pregnancy twice consecutively after having assisted reproductive technology.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n

      Steps of PGT<\/h3>\n

      The first step is as same as the IVF, starting from the ovarian stimulation to the fertilization preparation and \ngrowing the embryo to the appropriate phase for PGT, which is divided into three stages.<\/p>\n

        \n
      1. Oocyte before fertilization or the pre-embryonic stage. Polar body of oocyte or pre-embryonic stage.<\/li>\n
      2. The embryo divides on Day 3 after fertilization (Clevage Stage).<\/li>\n
      3. Embryo divides at Day 5 (Blastocyst Stage)<\/li>\n<\/ol>\n

        In general, the doctor examines the embryos at the Blastocyst Stage because there are enough cells for \nexamination with the fewest impact on the embryo growth and the difference of genetic materials in each cell might be \ndetected, which is called Mosaicism. When the embryo reaches the cell division stage and has enough cells in the \nplacenta, which is regularly 3-5 days after fertilization, the cells of each embryo are sucked under high magnification for \ngenetic testing to identify if the embryos are normal or not. Select the strongest embryo with no disease to transfer back \nto the uterus for implantation and pregnancy. Currently, the data of an infant born through this technique is at a high \nrate, and their development is normal. For this reason, it is acceptable that the infant born through this technique has no \ndifference from the infant born through a natural pregnancy. Therefore, the testing is the genetic test of the screening \ncells, and the obtained cells are the representatives of the entire cells of the embryo since the testing is more deliberate \nand complicated than testing with blood or other tissues because the genetic materials in one cell are low. As a result, \nthe testing requires accuracy, time, and high experience from doctors or scientists for the highest precision and less \ndisturbance to embryos.<\/p>\n

        PGT Technique<\/h3>\n

        Today, PGT has various techniques depending on the genetic disorder, single gene disorder, or numerical \naberration. Each technique has different complications and diagnosis precision.<\/p>\n

          \n
        1. Fluorescence Insitu hybridization (FISH) is a process that uses fluorescent probes to detect the target \nchromosome to determine the number of chromosome pairs, which are the 23rd, 18th, X, and Y chromosomes. \nThis technique requires a lower cost but gives a level of precision. However, it does not examine the genetic \nmaterials of all embryos, so it is not frequently used for embryo screening.<\/li>\n
        2. Comparative Genomic Hybridization (CGH) is the PGT technique by analyzing 23 pairs of chromosomes with the \nWhole Genome Amplification (WGA) technique and testing for the target genetic materials by labeling the genetic \nmaterials on embryo and standard genetic material to compare with the different fluorescent colors. Interpret the \nresult with a computer program after the reaction. Results identify the Aneuploidy, Unbalanced Translocation, or \nChromosome Deletion or Duplication. Nevertheless, this technique cannot analyze the abnormality of the \nbalanced translocation or inversion because such abnormalities do not differentiate the number of genetic \nmaterials from the standard one. The technique takes about 24-72 hours.<\/li>\n
        3. Next Generation Sequencing (NGS) is a currently popular technique. It is the technique to analyze the type and \nsequencing of embryo genetic material that detects the chromosome abnormality to the base sequence, which is \nthe smallest component of the chromosome. Therefore, it has high precision. The strength of this technique is \nthe abnormality detection of all 24 chromosomes with 99.9% precision within a short time. However, it cannot \ndetect the diseases caused by the single gene disorder, mosaicism, polyploidy, and aneuploidy of the genetic \nmaterials part in the small chromosome that the technique can detect, such as aneuploidy of the chromosomes\nthat are smaller than 10 megabase.<\/li>\n<\/ol>\n

          For treatment guidelines for a couple at Genesis Fertility Studio, a team of doctors gives the treatment guidelines \nand technique by individualization based on the current medical indication for the most appropriate and precise \noutcome at the appropriate time and cost to suit each couple. We ensure that the best technique and approaches \nare offered to you, along with the novel certified techniques.<\/p>\n

          Limitations to Preimplantation Genetic Diagnosis<\/h3>\n

          PGT has a limitation to the precision of results; the precision is 95-99%. However, this technique cannot replace \nthe prenatal diagnosis. Thus, even though the PGT results show normality, it is recommended to take prenatal diagnosis \nas same as the natural pregnancy. Besides, a couple should acknowledge the possibility of having the appropriate \nembryo for the transfer because the cause of infertility and the quality of gamete of each couple is different. \nPreimplantation genetic diagnosis might have a low number of normal embryos or different numbers of embryos in each \ncycle, especially in a person who has a screening for the disease caused by a single gene disorder, such as thalassemia, \nand HLA that matches with the child with the disease. Therefore, a couple might have to have ovarian stimulation to get \nthe appropriate and sufficient embryos for disease screening and pregnancy.<\/p>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

          [et_pb_section fb_built=”1″ module_class=”section-slider” _builder_version=”4.5.3″ _module_preset=”default” background_image=”http:\/\/ginafertilitystudio.com\/wp-content\/uploads\/2024\/07\/new-banner-services.jpg” custom_padding=”280px||||false|false” custom_css_main_element=”height: 800px;” global_module=”787″ saved_tabs=”all”][et_pb_row _builder_version=”4.16″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”text-align: center;”][et_pb_text admin_label=”\u0e02\u0e49\u0e2d\u0e04\u0e27\u0e32\u0e21” _builder_version=”4.5.3″ _module_preset=”default” header_2_font=”anuphan-regular||||||||” header_3_font=”anuphan-regular||||||||” header_3_font_size=”19px” text_orientation=”center” custom_padding=”20px||||false|false”] \u201c \u0e25\u0e39\u0e01\u0e04\u0e37\u0e2d\u0e1b\u0e32\u0e0f\u0e34\u0e2b\u0e32\u0e23\u0e34\u0e22\u0e4c \u0e41\u0e25\u0e30\u0e02\u0e2d\u0e07\u0e02\u0e27\u0e31\u0e0d\u0e41\u0e2b\u0e48\u0e07\u0e0a\u0e35\u0e27\u0e34\u0e15 \u0e17\u0e35\u0e48\u0e40\u0e23\u0e32\u0e2a\u0e23\u0e49\u0e32\u0e07\u0e44\u0e14\u0e49 \u201d Gina fertility studio [\/et_pb_text][et_pb_button button_url=”\/contact-us\/##contact-info” button_text=”\u0e2a\u0e19\u0e43\u0e08\u0e23\u0e31\u0e1a\u0e04\u0e33\u0e1b\u0e23\u0e36\u0e01\u0e29\u0e32” button_alignment=”center” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_bg_color=”rgba(0,0,0,0)” button_border_color=”#ffffff” button_border_radius=”10px” button_icon_color=”#ffffff”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.3″ _module_preset=”default” hover_enabled=”0″ background_enable_image=”off” background_color=”#fabfb7″][et_pb_row _builder_version=”4.5.3″ _module_preset=”default” custom_margin=”|auto||auto|false|false” […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":""},"_links":{"self":[{"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/pages\/513"}],"collection":[{"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/comments?post=513"}],"version-history":[{"count":9,"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/pages\/513\/revisions"}],"predecessor-version":[{"id":2884,"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/pages\/513\/revisions\/2884"}],"wp:attachment":[{"href":"http:\/\/ginafertilitystudio.com\/en\/wp-json\/wp\/v2\/media?parent=513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}